Food allergy: When and how to perform oral food challenges

@article{Sicherer1999FoodAW,
  title={Food allergy: When and how to perform oral food challenges},
  author={Scott H. Sicherer},
  journal={Pediatric Allergy and Immunology},
  year={1999},
  volume={10}
}
  • S. Sicherer
  • Published 1 November 1999
  • Medicine
  • Pediatric Allergy and Immunology
In many situations, the diagnosis of food allergy rests simply upon a history of an acute onset of typical symptoms, such as hives and wheezing, following the isolated ingestion of a suspected food, with confirmatory laboratory studies of positive prick skin tests or RASTs. However, the diagnosis is more complicated when multiple foods are implicated or when chronic diseases, such as asthma or atopic dermatitis, are evaluated. The diagnosis of food allergy and identification of the particular… 

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Some of the tests discussed in this chapter not only aid in the diagnosis of food allergies, but also are useful in monitoring the natural history of patients' food allergies over time, from diagnosis to oral tolerance.

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The most definitive test available to determine an adverse reaction to food is the physician-supervised oral food challenge (OFC), but ancillary tests are used to determine if a food allergy is likely and additional tests that are emerging with regard to their diagnostic value are shown.

Controlled oral food challenges in children – when indicated, when superfluous?

The current knowledge of predictors for the outcome of oral food challenges is reviewed and proposals for the daily practical work‐up in the case of suspected food related clinical symptoms are presented.

Food allergy in children

The medical care of a food allergic child requires concurrent dietary advice and management, risk avoidance and emergency management plans, and reintroduction of foods occurs when the risk profile is appropriate based mainly on the predictive information obtained by SPTs and specific IgE levels.

Food allergy in children.

The medical care of a food allergic child requires concurrent dietary advice and management, risk avoidance and emergency management plans, and reintroduction of foods occurs when the risk profile is appropriate based mainly on the predictive information obtained by SPTs and specific IgE levels.

Oral Food Challenges in Children: Review and Future Perspectives

The magnitude of the serum and skin tests may be of assistance in stratifying a patient’s risk of passing a challenge, and newer diagnostic tests may help better stratify such risk of based on particular epitope recognition.

Food allergies: detection and management.

Patients with anaphylactic reactions need emergent epinephrine and instruction in self-administration in the event of inadvertent exposure, and Antihistamines can be used for more minor reactions.

Diagnostic pitfalls in food allergy in children

There are several pitfalls in the diagnostic work‐up of food allergy, which may be misleading for the physician, as well as the problem of non‐IgE‐mediated reactions.

Beyond oral food challenges: improved modalities to diagnose food hypersensitivity disorders.

  • S. Sicherer
  • Medicine
    Current opinion in allergy and clinical immunology
  • 2003
The atopy patch test (APT), in which foods are applied to the skin under Finn chambers in a manner similar to that used with classic contact allergens in patch testing, has been investigated to address limitations, but this methodology is also limited by relatively low positive predictive accuracy.

Elimination Diet , Food Challenge Tools For Patients With Allergies

Soy-induced enterocolitis is an immunologic syndrome resulting in adverse gastrointestinal reactions to soy protein, but not systemically mediated by IgE, and soybean oil, a common food ingredient, is considered safe for those with a food allergy, depending on the processing method.
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