Food allergens

  title={Food allergens},
  author={Wesley A. Burks and Ricki M. Helm and Steven Stanley and G. A. Bannon},
  journal={Current Opinion in Allergy and Clinical Immunology},
A number of advances in the scientific knowledge concerning adverse food reactions have been made in the past few years. Understanding about the nature of the food allergen itself, the molecular characterization of the epitopes on these allergens, the pathophysiology of the clinical reaction, and the diagnostic methods have all been significantly enhanced. 
2 Citations
New insights into diagnosis and treatment of peanut food allergy.
There is no effective method to cure peanut allergy and the management of patients with peanut allergy focuses on preventing inadvertent ingestions of peanut, recognizing early signs of allergic reactions, and properly treating peanut-induced symptoms should they occur. Expand


Food allergy
Opinion statementAlthough many emerging therapies demonstrate theoretical and practical promise, strict elimination of the allergenic food remains the only proven therapy for food hypersensitivity.Expand
Characterization of Api g 1.0201, a New Member of the Api g 1 Family of Celery Allergens
Little is known about the IgE-binding capacity of isoforms of Bet v 1 homologues of food allergens, but identification and characterization of such isoforms may help to contribute to a better understanding of food allergy and the observed cross-reactivity to pollen allergy. Expand
Cross-reactivity and epitope analysis of Pru a 1, the major cherry allergen.
The investigation of essential features for preserving cross-reactive IgE-epitopes provides the structural basis for understanding the clinically observed cross-allergenicity between pollen and fruits. Expand
Immunologic cross-reactivity among cereal grains and grasses in children with food hypersensitivity.
Clinically insignificant cross-reactivity exists among cereal grains and grasses; therefore, elimination of all grains from the diet of a patient with grain allergy is unwarranted and protein fractions associated with wheat hypersensitivity are defined. Expand
Recombinant peanut allergen Ara h I expression and IgE binding in patients with peanut hypersensitivity.
With the production of the recombinant peanut protein it will now be possible to address the pathophysiologic and immunologic mechanisms regarding peanut hypersensitivity reactions specifically and food hypersensitivity in general. Expand
Molecular and biochemical classification of plant-derived food allergens.
Allergens other than PR homologs can be allotted to other well-known protein families such as inhibitors of alpha-amylases and trypsin from cereal seeds, profilins from fruits and vegetables, seed storage proteins from nuts and mustard seeds, and proteases from fruits. Expand
Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens.
The clinical reactivity in these 2 patients is likely due to cross-reacting IgE antibodies primarily directed against walnut, the original clinical allergy reported, and most likely to a walnut legumin-like protein. Expand
Immunochemical Analysis of Cod Fish Allergen M: Locations of the Immunoglobulin Binding Sites as Demonstrated by the Native and Synthetic Peptides
The suggested strucutre was based on the extensive intramolecular amino acid homologies and the immunochemical cross‐reactivities of the intact molecule and the two major isolated fragments, analogous to carp parvalbumin pI 4.25. Expand
Prospective appraisal of complaints of adverse reactions to foods in children during the first 3 years of life.
It is found that most food reactions occur during the first year of life, but rechallenge at regular intervals has shown that the food can be reintroduced into the diet by the third year without risk. Expand
Cross-allergenicity in the legume botanical family in children with food hypersensitivity.
Results of oral food challenges demonstrate that clinically important cross-reactivity to legumes in children is very rare and clinical hypersensitivity to one legume does not warrant dietary elimination of all legumes. Expand