Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial

@article{McCann2007FoodAA,
  title={Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial},
  author={Donna C. McCann and Angelina Barrett and Alison Cooper and Debbie Crumpler and Lindy Dalen and K E C Grimshaw and Elizabeth M. Kitchin and Kristel Lok and Lucy Porteous and Emily Prince and Edmund J S Sonuga-Barke and John O. Warner and Jim Stevenson},
  journal={The Lancet},
  year={2007},
  volume={370},
  pages={1560-1567}
}
BACKGROUND We undertook a randomised, double-blinded, placebo-controlled, crossover trial to test whether intake of artificial food colour and additives (AFCA) affected childhood behaviour. METHODS 153 3-year-old and 144 8/9-year-old children were included in the study. The challenge drink contained sodium benzoate and one of two AFCA mixes (A or B) or a placebo mix. The main outcome measure was a global hyperactivity aggregate (GHA), based on aggregated z-scores of observed behaviours and… Expand
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