Folylpolyglutamate synthesis and role in the regulation of one-carbon metabolism.

Abstract

The physiological importance of folylpolyglutamates is now well established. These derivatives are the intracellular substrates and regulators of one-carbon metabolism, and their synthesis is required for normal folate retention by tissues. Over the last few years, a considerable amount of information has been obtained on the mechanism by which these… (More)

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