Following specific podocyte injury captopril protects against progressive long term renal damage

@inproceedings{Zhou2015FollowingSP,
  title={Following specific podocyte injury captopril protects against progressive long term renal damage},
  author={Yu Zhou and Ihmoda A Ihmoda and Richard G Phelps and Christopher O S Bellamy and A. Neil Turner and Gavin I. Welsh and Johannes S Schlondorff and Taiji Matsusaka},
  booktitle={F1000Research},
  year={2015}
}
BACKGROUND Angiotensin converting enzyme inhibitors (ACEi) reduce proteinuria and preserve kidney function in proteinuric renal diseases. Their nephroprotective effect exceeds that attributable to lowering of blood pressure alone. This study examines the potential of ACEi to protect from progression of injury after a highly specific injury to podocytes in a mouse model. METHODS We created transgenic (Podo-DTR) mice in which graded specific podocyte injury could be induced by a single… CONTINUE READING
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