Follow-up on genome-wide main effects: do polymorphisms modify the air pollution effect on lung function decline in adults?

@article{Thun2014FollowupOG,
  title={Follow-up on genome-wide main effects: do polymorphisms modify the air pollution effect on lung function decline in adults?},
  author={Gian Andri Thun and Medea Imboden and Nino K{\"u}nzli and Thierry Rochat and Dirk Keidel and Margot Haun and Christian Schindler and Florian Kronenberg and Nicole Probst-Hensch},
  journal={Environment international},
  year={2014},
  volume={64},
  pages={110-5}
}
Improved air quality has been found associated with attenuated age-related decline in lung function. But whether genetic polymorphisms strongly associated with lung function play a modifying role in this attenuation process has so far not been investigated. We selected ten single nucleotide polymorphisms derived from the largest genome-wide association studies on lung function and examined whether they modified the association between the change in exposure to particulate matter ≤10μm (ΔPM10… CONTINUE READING