Follow-up of 316 molecularly defined pediatric long-QT syndrome patients: clinical course, treatments, and side effects.

@article{Koponen2015FollowupO3,
  title={Follow-up of 316 molecularly defined pediatric long-QT syndrome patients: clinical course, treatments, and side effects.},
  author={Mikael Koponen and Annukka Marjamaa and Anita Hiippala and J M Happonen and Aki S. Havulinna and Veikko V Salomaa and Annukka M. Lahtinen and Taina Hintsa and Matti Viitasalo and Lauri Toivonen and Kimmo K. Kontula and Heikki Swan},
  journal={Circulation. Arrhythmia and electrophysiology},
  year={2015},
  volume={8 4},
  pages={815-23}
}
BACKGROUND Inherited long-QT syndrome (LQTS) is associated with risk of sudden death. We assessed the clinical course and the fulfillment of current treatment strategies in molecularly defined pediatric LQTS type 1 and (LQT1) and type 2 (LQT2) patients. METHODS AND RESULTS Follow-up data covering a mean of 12 years were collected for 316 genotyped LQT1 and LQT2 patients aged 0 to 18 years. No arrhythmic deaths occurred during the follow-up. Finnish KCNQ1 and KCNH2 founder mutations were… CONTINUE READING
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