Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis.

@article{Yao2004FollistatinOD,
  title={Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis.},
  author={Humphrey Hung-Chang Yao and Martin M. Matzuk and Carolina J Jorgez and Douglas B Menke and David C Page and Amanda Swain and Blanche Capel},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2004},
  volume={230 2},
  pages={
          210-5
        }
}
Wnt4(-/-) XX gonads display features normally associated with testis differentiation, suggesting that WNT4 actively represses elements of the male pathway during ovarian development. Here, we show that follistatin (Fst), which encodes a TGFbeta superfamily binding protein, is a downstream component of Wnt4 signaling. Fst inhibits formation of the XY-specific coelomic vessel in XX gonads. In addition, germ cells in the ovarian cortex are almost completely lost in both Wnt4 and Fst null gonads… CONTINUE READING
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