Follistatin-like protein 1 promotes arthritis by up-regulating IFN-gamma.

  title={Follistatin-like protein 1 promotes arthritis by up-regulating IFN-gamma.},
  author={Suzanne D Clutter and David R. Wilson and Anthony D. Marinov and Raphael Hirsch},
  journal={Journal of immunology},
  volume={182 1},
Follistatin-like protein-1 (FSTL-1) is a poorly characterized protein that is up-regulated in the early stage of collagen-induced arthritis and that exacerbates arthritis when delivered by gene transfer. The current study was designed to determine the mechanism by which FSTL-1 promotes arthritis. FSTL-1 was injected into mouse paws, resulting in severe paw swelling associated with up-regulation of IFN-gamma transcript and the IFN-gamma-induced chemokine, CXCL10. Mice depleted of T cells were… CONTINUE READING
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