Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart.

@article{Oshima2008Follistatinlike1I,
  title={Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart.},
  author={Yuichi Oshima and Noriyuki Ouchi and Kaori Sato and Yasuhiro Izumiya and David R. Pimentel and Kenneth Walsh},
  journal={Circulation},
  year={2008},
  volume={117 24},
  pages={3099-108}
}
BACKGROUND The Akt protein kinase is an important mediator of cardiac myocyte growth and survival. To identify factors with novel therapeutic applications in cardiac diseases, we focused on the identification of factors secreted from Akt1-activated cells that have cardioprotective effects through autocrine/paracrine mechanisms. METHODS AND RESULTS Using an inducible Akt1 transgenic mouse model, we have found that follistatin-like 1 (Fstl1) protein and transcript expression are increased 4.0… CONTINUE READING

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