Follistatin-like 1 attenuates apoptosis via disco-interacting protein 2 homolog A/Akt pathway after middle cerebral artery occlusion in rats.

@article{Liang2014Follistatinlike1A,
  title={Follistatin-like 1 attenuates apoptosis via disco-interacting protein 2 homolog A/Akt pathway after middle cerebral artery occlusion in rats.},
  author={Xiping Liang and Qin Hu and Bo Li and Devin William McBride and Hetao Bian and Pierre Spagnoli and Di Chen and Jiping Tang and John H Zhang},
  journal={Stroke},
  year={2014},
  volume={45 10},
  pages={3048-3054}
}
BACKGROUND AND PURPOSE Follistatin-like 1 (FSTL1), an extracellular glycoprotein, has been reported to decrease apoptosis in ischemic cardiac diseases, but its effect in ischemic stroke has not been examined. We hypothesized that recombinant FSTL1 attenuates neuronal apoptosis through its receptor disco-interacting protein 2 homolog A (DIP2A) and the Akt pathway after middle cerebral artery occlusion (MCAO) in rats. METHODS One hundred forty male Sprague-Dawley rats were subjected to 2 hours… CONTINUE READING
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