Follicular thyroid tumors with the PAX8-PPARgamma1 rearrangement display characteristic genetic alterations.

@article{Lacroix2005FollicularTT,
  title={Follicular thyroid tumors with the PAX8-PPARgamma1 rearrangement display characteristic genetic alterations.},
  author={Ludovic Lacroix and Vladimir Lazar and Stefan Michiels and Hugues Ripoche and Philippe Dessen and Monique Talbot and Bernard Caillou and Jean-Pierre Levillain and Martin Schlumberger and J M Bidart},
  journal={The American journal of pathology},
  year={2005},
  volume={167 1},
  pages={223-31}
}
Follicular thyroid carcinomas (FTC) arise through oncogenic pathways distinct from those involved in the papillary histotype. Recently, a t(2;3)(q13;p25) rearrangement, which juxtaposes the thyroid transcription factor PAX8 to the peroxisome proliferator-activated receptor (PPAR) gamma1, was described in FTCs. In this report, we describe gene expression in 11 normal tissues, 4 adenomas, and 8 FTCs, with or without the PAX8-PPARgamma1 translocation, using custom 60-mer oligonucleotide… CONTINUE READING