Follicular thyroid cancer and Hürthle cell carcinoma: challenges in diagnosis, treatment, and clinical management.

  title={Follicular thyroid cancer and H{\"u}rthle cell carcinoma: challenges in diagnosis, treatment, and clinical management.},
  author={Giorgio Grani and Livia Lamartina and Cosimo Durante and Sebastiano Filetti and David S Cooper},
  journal={The lancet. Diabetes \& endocrinology},
  volume={6 6},

Tables from this paper

Recurrent Hurthle cell thyroid carcinoma does not preclude long-term survival: a case report and review of the literature

This case exemplifies that thorough aftercare and aggressive treatment enables long-term survival even in recurrent Hurthle cell thyroid carcinoma displaying unusual multisite metastases, and demonstrates the importance of consistent aftercare.

Advancements in the treatment of differentiated thyroid cancer

  • L. StewartJ. Kuo
  • Medicine, Biology
    Therapeutic advances in endocrinology and metabolism
  • 2021
Although surgery and radioiodine ablation remain the mainstay of DTC therapy, the role of active surveillance is being explored and the most recent American Thyroid Association guidelines offer flexibility between lobectomy and total thyroidectomy for thyroid nodules between 1’cm and 4 cm in the absence of extrathyroidal extension or nodal disease.

Clinical impact of follicular oncocytic (Hürthle cell) carcinoma in comparison with corresponding classical follicular thyroid carcinoma

The study suggests that recurrence is more often seen in OFTC patients, who have a poorer prognosis for disease-free survival than FTC patients after initial RIT.


Overall survival was associated with tumour size rather than histopathological subtype and there is an important need to perform further studies to assess the effectiveness of treatment strategies.

Multimodal imaging of thyroid cancer

The mainstay of diagnosing thyroid cancer is thyroid ultrasound with ultrasound-guided FNB, and contrast-enhanced computed tomography and PET with [ 18F]-fluorodeoxyglucose (FDG) and MRI are reserved for advanced and/or recurrent cases of differentiated thyroid cancer and anaplastic thyroid cancer, while [18F]FDOPA and [68Ga]DOTATOC are the preferred tracers for medullary thyroid cancer.

Thyroid Hürthle Cell Carcinoma: Clinical, Pathological, and Molecular Features

Current knowledge of Hürthle cell carcinoma, including clinical, pathological, and molecular features, with the aim of improving clinical management, is reviewed.

A Patient with a Large Minimally Invasive Follicular Thyroid Cancer

The diagnostic criteria for MIFC are still controversial which has led to differing recommendations as to the appropriate extent of treatment for patients with MIFC, ranging from thyroid lobectomy alone to total thyroidectomy and postoperative radioactive iodine ablation (RAI).

A Patient with a Large Hürthle Cell Carcinoma of the Thyroid and Nodal Metastases

The case illustrates the difficulty in differential diagnosis based upon cytology alone and the need for aggressive initial management with surgery and radioiodine when there is pathologic evidence of a highly invasive nature of the tumor.

Follicular Thyroid Cancer

Radioiodine Refractory Follicular Thyroid Cancer and Surgery for Cervical Relapse

In conclusion, surgery for cervical radioiodine refractory FTC relapse is often performed in metastatic setting, and cure is rare, although metastases can appearRadioiodine avid.



Follicular thyroid carcinoma

The differential diagnosis between follicular carcinomas and three tumor types—follicular adenoma, follicular variant of papillary carcinoma and poorly differentiated carcinoma—as well as the problems raised by the newly described categories of follicular tumors are addressed.

The History of the Follicular Variant of Papillary Thyroid Carcinoma.

The encapsulated/well-demarcated, noninvasive form of FVPTC was renamed as non invasive follicular thyroid neoplasm with papillary-like nuclear features, enabling clinicians to avoid aggressive therapy.

Clinical and molecular features of Hürthle cell carcinoma of the thyroid.

Widely invasive HCC with TNM stage III-IV is aggressive, with low probability of recurrence-free survival, and males have worse outcomes than females, while minimally invasive H CC appears to be considerably less aggressive.

Differentiated thyroid carcinoma: defining new paradigms for postoperative management.

This review examines some of the key issues in this area, including the assessment of risks for disease recurrence and thyroid cancer-related death, the indications for postoperative ablation of the thyroid remnant with radioactive iodine and TSH-suppressive doses of levothyroxine, the pros, cons, and rationales for the use of various follow-up tools.

A Bedside Risk Calculator to Preoperatively Distinguish Follicular Thyroid Carcinoma from Follicular Variant of Papillary Thyroid Carcinoma

Trends in rates of FTC versus FV-PTC in the U.S. are described and a risk assessment tool is developed to aid clinicians in predicting final diagnosis and shaping treatment plans to aid patient and clinician discussions and decision making.

Follicular Thyroid Carcinoma: How Have Histologic Diagnoses Changed in the Last Half-Century and What Are the Prognostic Implications?

The aims of this study were to review FTC histologically at the authors' tertiary care institution and to evaluate long-term survival and recurrence.

Prognostic factors of recurrence in encapsulated Hurthle cell carcinoma of the thyroid gland

The current study attempted to identify predictors of recurrence in EHC, and focused on the encapsulated Hurthle cell carcinoma (EHC).

Well-Differentiated Thyroid Cancer: The Philippine General Hospital Experience

Overall, PTC among Filipino was associated with a more aggressive and recurrent behavior, and FTC among Filipinos appeared to behave similarly with other racial groups.

Can Minimally Invasive Follicular Thyroid Cancer be Approached as a Benign Lesion?

Thyroid lobectomy alone may be considered adequate treatment in these patients with MIFC and is associated with survival comparable to that of the normative US general population.