Follicular mechanisms associated with 4-vinylcyclohexene diepoxide-induced ovotoxicity in rats.

@article{Springer1996FollicularMA,
  title={Follicular mechanisms associated with 4-vinylcyclohexene diepoxide-induced ovotoxicity in rats.},
  author={Leopold Springer and Jodi Anne Flaws and I. Glenn Sipes and Patricia B.. Hoyer},
  journal={Reproductive toxicology},
  year={1996},
  volume={10 2},
  pages={
          137-43
        }
}
The mechanism of 4-vinylcyclohexene diepoxide (VCD)-induced oocyte destruction in small preantral follicles of rats and mice has not been elucidated. This study examined the effects of daily dosing of female rats with VCD on protein synthesis and follicle viability. An investigation of granulosa cells as a target for VCD was also made. Small preantral follicles (25 to 100 microns) isolated from untreated immature rats (day 28) as well as from rats injected daily for 10 d with VCD (0.57 mmol/kg… CONTINUE READING
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