Follicular lymphoma transformed to “double‐hit” B lymphoblastic lymphoma presenting in the peritoneal fluid

  title={Follicular lymphoma transformed to “double‐hit” B lymphoblastic lymphoma presenting in the peritoneal fluid},
  author={Alesia Kaplan and Arbaz Samad and Michelle M. Dolan and Adina M. Cioc and Carol J Holman and Stephen C Schmechel and Stefan E. Pambuccian},
  journal={Diagnostic Cytopathology},
Lymphomas showing both MYC/8q24 rearrangement and IGH@BCL2/t(14;18)(q32;q21), also referred to as “double‐hit” or “dual‐hit” lymphomas (DHL) are rare B‐cell malignancies with a germinal center B‐cell immunophenotype and heterogeneous cytologic and histologic features. Such lymphomas may arise de novo or through transformation of follicular lymphomas and are classified either as “B‐cell lymphoma, unclassifiable, with features intermediate between diffuse large B‐cell lymphoma (DLBCL) and Burkitt… 
EBV‐associated but HHV8‐unrelated double‐hit effusion‐based lymphoma
This is the first reported case of double‐hit effusion‐based lymphoma with MYC and BCL2 rearrangement and illustrates the importance of integrating clinical, cytological, immunophenotypical, and molecular findings to reach a correct diagnosis.
“Double hit” B-lymphoblastic lymphoma with concurrent IGH/BCL2 and 8q24/MYC translocations: a case report
The patient showed an initial response to six cycles of hyper-CVAD chemotherapy (hyper-fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone) and was alive at the last follow-up (2020.4.10, six months after the diagnosis).
Transformation of Follicular Lymphoma to Double Hit B-Cell Lymphoma Causing Hypercalcemia in a 69-Year-Old Female: A Case Report and Review of the Literature
This paper highlights not only transformation of follicular lymphoma to double hit B-cell lymphoma and the challenges encountered in diagnosing and treating these aggressive tumors, but also the association of new onset/worsening hypercalcemia in such patients.
Double-hit pancreatic B-lymphoblastic lymphoma with a variant translocation t(2;18)(p11;q21)
This is the first reported case of MYC and BCL2 double-hit B-LBL with a variant translocation t(2;18)(p11;q21), and high coexpression of MyC by t(8;14) and B CL2 by t (2; 18) may be implicated in the development of B- LBL.
De novo double-hit B-cell precursor leukemia/lymphoma - an unusual presentation as peritoneal lymphomatosis
Autopsy findings of PL are illustrated in an elderly gentleman who presented with ascites for evaluation, establishing a diagnosis of de novo B-cell precursor leukemia/lymphoma with MYC, BCL2 rearrangements (Double-hit lymphoma).
Flow Cytometric Evaluation of Double/Triple Hit Lymphoma
Although there is some overlap with B-LBL, D/THL demonstrates a characteristic immunophenotype which may have prognostic significance and warrants further investigation.
Case Report: Concurrent Occurrence of Abdominal Double Expressor Lymphoma and Jejunum Follicular Lymphoma
This case is unique in that concurrent occurrence of FL and DEL was confirmed by immunohistochemical and FISH analyses and that abdominal DEL transformed from jejunal FL was highly suspected.
High-grade B-cell lymphomas with TdT expression: a diagnostic and classification dilemma
In patients with TdT-positive aggressive B-cell lymphoma, the cytogenetic findings and poor prognosis suggest that these neoplasms need to be distinguished from B-lymphoblastic leukemia/lymphoma.
Double- and triple-hit lymphomas can present with features suggestive of immaturity, including TdT expression, and create diagnostic challenges
It is concluded that expression of TdT in a B-cell lymphoma with mature features or expression of surface light chain in a case otherwise suggestive of B-lymphoblastic leukemia/lymphoma should prompt an expedited evaluation for DHL/THL.


B-cell lymphomas with MYC/8q24 rearrangements and IGH@BCL2/t(14;18)(q32;q21): an aggressive disease with heterogeneous histology, germinal center B-cell immunophenotype and poor outcome
It is concluded that MYC/BCL2 lymphomas are clinically aggressive, irrespective of their morphological appearance, with a germinal center B-cell immunophenotype.
Double-hit B-cell lymphomas.
The existing literature for the most recurrent types of DH B-cell lymphomas and the involved genes with their functions, as well as their pathology and clinical aspects including therapy and prognosis are explored.
B-cell Lymphomas With Concurrent IGH-BCL2 and MYC Rearrangements Are Aggressive Neoplasms With Clinical and Pathologic Features Distinct From Burkitt Lymphoma and Diffuse Large B-cell Lymphoma
DHL is a high-grade B-cell neoplasm with a poor prognosis, resistance to multiagent chemotherapy, and clinical and pathologic features distinct from other high- grade B- cell neoplasms.
"Double-Hit" mature B-cell lymphomas show a common immunophenotype by flow cytometry that includes decreased CD20 expression.
It is shown that these cases frequently showed a common immunophenotype that includes decreased expression of CD20, which may be useful for identifying cases for confirmatory cytogenetic studies, as often, flow cytometry provides the first assessment of these clinical specimens.
C-MYC translocation in t(14;18) positive follicular lymphoma at presentation: An adverse prognostic indicator?
The possibility that the presence of a C-MYC translocations at presentation may identify a particularly aggressive subtype of FL is raised, which raises the possibility that a poor prognosis in cases of FL may be identified.
B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma
A new category in the 2008 World Health Organization’s classification of hematologic neoplasms, which includes cases that have features of both diseases but which cannot be classified easily into either, is a new category of lymphomas with overlapping features.
Precursor B-lymphoblastic transformation of grade I follicle center lymphoma.
A rare example of a precursor B-lymphoblastic transformation of grade I FCL occurring in a 45-year-old woman 12 years after initial presentation and 3 years after successful treatment for a diffuse large cell transformation is described.
Cytomorphologic findings of B‐cell lymphomas with concurrent IGH/BCL2 and MYC rearrangements (dual‐translocation lymphomas)
The objective of this study was to review and describe the cytomorphologic findings in different types of cytologic preparations and clinicopathologic characteristics of patients with DTLs.
Activation of the c-myc oncogene in a precursor-B-cell blast crisis of follicular lymphoma, presenting as composite lymphoma.
B-CELL lymphomas are considered to represent "frozen" stages in the maturation of normal B cells. However, progression to a more malignant histologic form is frequently observed in low-grade
Cytopathology of “double‐hit” non‐Hodgkin lymphoma
B‐cell lymphomas with concurrent IGH‐BCL2 and c‐MYC rearrangements (so‐called “double‐hit lymphomas” [DHL]) are a relatively rare, recently described category in the 2008 World Health Organization