Follicular lymphoma transformed to “double‐hit” B lymphoblastic lymphoma presenting in the peritoneal fluid

@article{Kaplan2013FollicularLT,
  title={Follicular lymphoma transformed to “double‐hit” B lymphoblastic lymphoma presenting in the peritoneal fluid},
  author={Alesia Kaplan and Arbaz Samad and Michelle M. Dolan and Adina M. Cioc and Carol J Holman and Stephen C Schmechel and Stefan E. Pambuccian},
  journal={Diagnostic Cytopathology},
  year={2013},
  volume={41}
}
Lymphomas showing both MYC/8q24 rearrangement and IGH@BCL2/t(14;18)(q32;q21), also referred to as “double‐hit” or “dual‐hit” lymphomas (DHL) are rare B‐cell malignancies with a germinal center B‐cell immunophenotype and heterogeneous cytologic and histologic features. Such lymphomas may arise de novo or through transformation of follicular lymphomas and are classified either as “B‐cell lymphoma, unclassifiable, with features intermediate between diffuse large B‐cell lymphoma (DLBCL) and Burkitt… 
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TLDR
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TLDR
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It is concluded that MYC/BCL2 lymphomas are clinically aggressive, irrespective of their morphological appearance, with a germinal center B-cell immunophenotype.
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TLDR
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TLDR
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B-CELL lymphomas are considered to represent "frozen" stages in the maturation of normal B cells. However, progression to a more malignant histologic form is frequently observed in low-grade
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B‐cell lymphomas with concurrent IGH‐BCL2 and c‐MYC rearrangements (so‐called “double‐hit lymphomas” [DHL]) are a relatively rare, recently described category in the 2008 World Health Organization
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