Follicular lymphoma: 2012 update on diagnosis and management
@article{Freedman2012FollicularL2, title={Follicular lymphoma: 2012 update on diagnosis and management}, author={Arnold S Freedman}, journal={American Journal of Hematology}, year={2012}, volume={87} }
Disease overview: Follicular lymphoma (FL) is generally an indolent B‐cell lymphoproliferative disorder of transformed follicular center B cells. FL is characterized by diffuse lymphoadenopathy, involvement of bone marrow, splenomegaly, and less commonly other extranodal sites of involvement. In general, cytopenias can occur but constitutional symptoms of fever, nightsweats, and weight loss are uncommon.
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References
SHOWING 1-10 OF 114 REFERENCES
Treatment of follicular non-Hodgkin's lymphoma: the old and the new.
- Biology, MedicineSeminars in hematology
- 2008
Despite remaining an incurable disease, overall survival improvements have been noted in patients with advanced-stage follicular lymphoma and the FLIPI is a robust prognostic index in this disease, and continues to provide prognostic information in the rituximab era.
Fludarabine, cyclophosphamide, and rituximab for the treatment of patients with chronic lymphocytic leukemia or indolent non‐hodgkin lymphoma
- Medicine, BiologyCancer
- 2006
The combination of fludarabine, cyclophosphamide, and rituximab (FC‐R) shows significant in vitro synergism and may improve patient outcome with little overlapping toxicity.
Prognosis in follicular lymphoma--it's in the microenvironment.
- Medicine, BiologyThe New England journal of medicine
- 2004
A large number of markers that predict the clinical behavior of B-cell lymphomas are still poorly understood, and further research is needed to understand why these markers are so poorly understood.
Improved survival in patients with early stage low‐grade follicular lymphoma treated with radiation
- MedicineCancer
- 2010
External beam radiation therapy is the standard treatment for stage I‐II, grade 1‐2 follicular lymphoma and the relative improvement in outcomes for patients treated with and without RT has never been tested in randomized trials.
Follicular large cell lymphoma: an aggressive lymphoma that often presents with favorable prognostic features.
- MedicineBlood
- 1999
With a median follow-up of 67 months, the 5-year survival is 72% and the failure-free survival (FFS) is 67%, with a possible plateau in the FFS curve, particularly for patients with stage I-III disease.
Transformation of indolent B-cell lymphomas.
- MedicineJournal of clinical oncology : official journal of the American Society of Clinical Oncology
- 2011
It is crucial to incorporate HT as a major end point in clinical trials and to include patients with HT as subject of such studies if the authors are to see meaningful progress in the future.
Prognostic factors in follicular lymphoma.
- Biology, MedicineJournal of clinical oncology : official journal of the American Society of Clinical Oncology
- 2010
There is a need for useful biomarkers for prediction of the disease course of single patients to individualize therapy, especially in the new era of chemoimmunotherapy.
Primary follicular lymphoma of the duodenum is a distinct mucosal/submucosal variant of follicular lymphoma: a retrospective study of 63 cases.
- MedicineJournal of clinical oncology : official journal of the American Society of Clinical Oncology
- 2011
These findings characterize primary FL-D as a remarkably indolent FL variant, which, even left untreated, does not develop tumorous growth, very rarely disseminates and does not transform to high grade disease.
Long‐term responses in patients with recurring or refractory B‐cell non‐Hodgkin lymphoma treated with yttrium 90 ibritumomab tiuxetan
- Biology, MedicineCancer
- 2007
Radioimmunotherapy with radiolabeled monoclonal antibodies to CD20 produces a high response rate in patients with recurring non‐Hodgkin lymphoma (NHL), but the durability of those remissions is not…
Clinical features and prognosis of follicular large-cell lymphoma: a report from the Nebraska Lymphoma Study Group.
- MedicineJournal of clinical oncology : official journal of the American Society of Clinical Oncology
- 1993
A proportion of stage I/II FLCL patients may obtain long-term disease control with combination chemotherapy plus radiotherapy and significantly poorer survival was only seen in patients older than 70 years of age.