Follicular helper T cells in immunity and systemic autoimmunity

  title={Follicular helper T cells in immunity and systemic autoimmunity},
  author={Joseph E Craft},
  journal={Nature Reviews Rheumatology},
Follicular helper T (TFH) cells are essential for B-cell maturation and immunoglobulin production after immunization with thymus-dependent antigens. Nevertheless, the development and function of TFH cells have been less clearly defined than classic CD4+ effector T-cell subsets, including T-helper-1 (TH1), TH2 and TH17 cells. As such, our understanding of the genesis of TFH cells in humans and their role in the development of autoimmunity remains incomplete. However, evidence from animal models… CONTINUE READING
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