Follicular helper T cells are required for systemic autoimmunity

  title={Follicular helper T cells are required for systemic autoimmunity},
  author={Michelle A Linterman and Robert J. Rigby and Raphael. K. Wong and Di Yu and Robert Brink and Jennifer L. Cannons and Pamela L Schwartzberg and Matthew C. Cook and Giles Walters and Carola G. Vinuesa},
  booktitle={The Journal of experimental medicine},
Production of high-affinity pathogenic autoantibodies appears to be central to the pathogenesis of lupus. Because normal high-affinity antibodies arise from germinal centers (GCs), aberrant selection of GC B cells, caused by either failure of negative selection or enhanced positive selection by follicular helper T (T(FH)) cells, is a plausible explanation for these autoantibodies. Mice homozygous for the san allele of Roquin, which encodes a RING-type ubiquitin ligase, develop GCs in the… CONTINUE READING


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