Follicular helper NKT cells induce limited B cell responses and germinal center formation in the absence of CD4(+) T cell help.

@article{Tonti2012FollicularHN,
  title={Follicular helper NKT cells induce limited B cell responses and germinal center formation in the absence of CD4(+) T cell help.},
  author={Elena Tonti and M. Fedeli and Anna Napolitano and Matteo Iannacone and Ulrich H von Andrian and Luca G. Guidotti and Sergio Abrignani and Giulia Casorati and Paolo Dellabona},
  journal={Journal of immunology},
  year={2012},
  volume={188 7},
  pages={3217-22}
}
B cells require MHC class II (MHC II)-restricted cognate help and CD40 engagement by CD4(+) T follicular helper (T(FH)) cells to form germinal centers and long-lasting Ab responses. Invariant NKT (iNKT) cells are innate-like lymphocytes that jumpstart the adaptive immune response when activated by the CD1d-restricted lipid α-galactosylceramide (αGalCer). We previously observed that immunization of mice lacking CD4(+) T cells (MHC II(-/-)) elicits specific IgG responses only when protein Ags are… CONTINUE READING