Follicular exclusion of autoreactive B cells requires FcgRIIb

Abstract

In non-autoimmune mice, the 3H9 transgenic Ig heavy chain can pair with endogenous Igl1 light chains to generate B cells with specificity for DNA. These autoreactive cells are actively regulated in vivo, as indicated by the exclusion of l1 cells from the splenic B cell follicle and the absence of auto-antibody production. To study the role of Fcg receptor… (More)

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