Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8

@article{Kranich2008FollicularDC,
  title={Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8},
  author={Jan Kranich and Nike Julia Krautler and Ernst Heinen and Magdalini Polymenidou and Claire Bridel and Anita Schildknecht and Christoph Huber and Marie H. Kosco-Vilbois and Rolf Martin Zinkernagel and Gino Miele and Adriano Aguzzi},
  journal={The Journal of Experimental Medicine},
  year={2008},
  volume={205},
  pages={1293 - 1302}
}
The secreted phosphatidylserine-binding protein milk fat globule epidermal growth factor 8 (Mfge8) mediates engulfment of apoptotic germinal center B cells by tingible-body macrophages (TBMphis). Impairment of this process can contribute to autoimmunity. We show that Mfge8 is identical to the mouse follicular dendritic cell (FDC) marker FDC-M1. In bone-marrow chimeras between wild-type and Mfge8(-/-) mice, all splenic Mfge8 was derived from FDCs rather than TBMphis. However, Mfge8(-/-) TBMphis… CONTINUE READING

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