Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells.

@article{Tew1997FollicularDC,
  title={Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells.},
  author={J. Grant Tew and Jun-ying Wu and Dahui Qin and Shirley L. T. Helm and Gregory F. Burton and Andras K. Szakal},
  journal={Immunological reviews},
  year={1997},
  volume={156},
  pages={39-52}
}
This review focuses on how immunogens trapped by FDC in the form of Ag-Ab complexes productively signal B cells. In vitro. Ag-Ab complexes are poorly immunogenic but in vivo immune complexes elicit potent recall responses. FDC trap Ag-Ab complexes and make immune complex coated bodies or "iccosomes". B cells endocytose iccosomes, the Ag is processed, and T-cell help is elicited. In vitro, addition of FDC bearing appropriate Ag-Ab complex to memory T and B cells provoke potent recall responses… CONTINUE READING

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