Follicular dendritic cells: origin, phenotype, and function in health and disease.

@article{Aguzzi2014FollicularDC,
  title={Follicular dendritic cells: origin, phenotype, and function in health and disease.},
  author={Adriano Aguzzi and Jan Kranich and Nike Julia Krautler},
  journal={Trends in immunology},
  year={2014},
  volume={35 3},
  pages={105-13}
}
Follicular dendritic cells (FDCs) were originally identified by their specific morphology and by their ability to trap immune-complexed antigen in B cell follicles. By virtue of the latter as well as the provision of chemokines, adhesion molecules, and trophic factors, FDCs participate in the shaping of B cell responses. Importantly, FDCs also supply tingible body macrophages (TBMs) with the eat-me-signaling molecule milk fat globule-EGF factor 8 (Mfge8), thereby enabling the disposal of… CONTINUE READING
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