Follicular dendritic cell-dependent drug resistance of non-Hodgkin lymphoma involves cell adhesion-mediated Bim down-regulation through induction of microRNA-181a.

@article{Lwin2010FollicularDC,
  title={Follicular dendritic cell-dependent drug resistance of non-Hodgkin lymphoma involves cell adhesion-mediated Bim down-regulation through induction of microRNA-181a.},
  author={Tint Lwin and Jianhong Lin and Yong Sung Choi and Xinwei Zhang and Lynn C. Moscinski and Kenneth L. Wright and Eduardo M. Sotomayor and William S Dalton and Jianguo Tao},
  journal={Blood},
  year={2010},
  volume={116 24},
  pages={5228-36}
}
Follicular dendritic cells (FDCs), an essential component of the lymph node microenvironment, regulate and support B-lymphocyte differentiation, survival, and lymphoma progression. Here, we demonstrate that adhesion of mantle cell lymphoma and other non-Hodgkin lymphoma cells to FDCs reduces cell apoptosis and is associated with decreased levels of the proapoptotic protein, Bim. Bim down-regulation is posttranscriptionally regulated via up-regulation of microRNA-181a (miR-181a). miR-181a… CONTINUE READING
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