Follicular cells of the thyroid gland require Pax8 gene function

@article{Mansouri1998FollicularCO,
  title={Follicular cells of the thyroid gland require Pax8 gene function},
  author={A. Mansouri and K. Chowdhury and P. Gruss},
  journal={Nature Genetics},
  year={1998},
  volume={19},
  pages={87-90}
}
The thyroid gland develops from two distinct embryonic lineages: follicular cells (which produce thyroxine) and parafollicular C-cells (which produce calcitonin) are of endodermal and neural crest origin, respectively. Little is known about the molecular mechanisms governing the generation of these different cell types. Mice lacking the transcription factor Ttf 1 lack both cell types and thus are unable to develop a thyroid gland. By analysis of Pax8−/− mice, we demonstrate that Pax8 is… Expand
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