Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility

@article{Xu2013FollicularTC,
  title={Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility},
  author={Heping Xu and Xuanying Li and Dan Liu and Jianfu Li and Xu Zhang and Xin Chen and Shiyue Hou and Lixia Peng and Chenguang Xu and Wanli Liu and Lianfeng Zhang and Hai Qi},
  journal={Nature},
  year={2013},
  volume={496},
  pages={523-527}
}
Germinal centres support antibody affinity maturation and memory formation. Follicular T-helper cells promote proliferation and differentiation of antigen-specific B cells inside the follicle. A genetic deficiency in the inducible co-stimulator (ICOS), a classic CD28 family co-stimulatory molecule highly expressed by follicular T-helper cells, causes profound germinal centre defects, leading to the view that ICOS specifically co-stimulates the follicular T-helper cell differentiation program… CONTINUE READING