Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection

@article{He2016FollicularCC,
  title={Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection},
  author={R. He and Shiyue Hou and C. Liu and Anli Zhang and Qiang Bai and Miao Han and Yu Yang and Gang Wei and T. Shen and X. Yang and Lifan Xu and X. Chen and Yaxing Hao and Pengcheng Wang and Chuhong Zhu and Juan-juan Ou and Houjie Liang and T. Ni and Xiaoyan Zhang and X. Zhou and K. Deng and Yaokai Chen and Yadong Luo and Jianqing Xu and Hai Qi and Yuzhang Wu and L. Ye},
  journal={Nature},
  year={2016},
  volume={537},
  pages={412-416}
}
During chronic viral infection, virus-specific CD8+ T cells become exhausted, exhibit poor effector function and lose memory potential. However, exhausted CD8+ T cells can still contain viral replication in chronic infections, although the mechanism of this containment is largely unknown. Here we show that a subset of exhausted CD8+ T cells expressing the chemokine receptor CXCR5 has a critical role in the control of viral replication in mice that were chronically infected with lymphocytic… Expand
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