Follicle-stimulating hormone regulates expression and activity of epidermal growth factor receptor in the murine ovarian follicle.

@article{ElHayek2014FolliclestimulatingHR,
  title={Follicle-stimulating hormone regulates expression and activity of epidermal growth factor receptor in the murine ovarian follicle.},
  author={Stephany El-Hayek and Isabelle Demeestere and Hugh J Clarke},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 47},
  pages={16778-83}
}
Fertility depends on the precise coordination of multiple events within the ovarian follicle to ensure ovulation of a fertilizable egg. FSH promotes late follicular development, including expression of luteinizing hormone (LH) receptor by the granulosa cells. Expression of its receptor permits the subsequent LH surge to trigger the release of ligands that activate EGF receptors (EGFR) on the granulosa, thereby initiating the ovulatory events. Here we identify a previously unknown role for FSH… CONTINUE READING
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