Follicle-stimulating hormone increases bone mass in female mice.

@article{Allan2010FolliclestimulatingHI,
  title={Follicle-stimulating hormone increases bone mass in female mice.},
  author={Charles M. Allan and Robert Kalak and Colin Robert Dunstan and Kirsten J. McTavish and Hong Zhou and David J Handelsman and Markus J Seibel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 52},
  pages={
          22629-34
        }
}
Elevated follicle-stimulating hormone (FSH) activity is proposed to directly cause bone loss independent of estradiol deficiency in aging women. Using transgenic female mice expressing human FSH (TgFSH), we now reveal that TgFSH dose-dependently increased bone mass, markedly elevating tibial and vertebral trabecular bone volume. Furthermore, TgFSH stimulated a striking accrual of bone mass in hypogonadal mice lacking endogenous FSH and luteinizing hormone (LH) function, showing that FSH-induced… CONTINUE READING
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