Follicle-stimulating hormone--regulated granulosa cell steroidogenesis: involvement of the calcium-calmodulin system.

@article{Carnegie1983FolliclestimulatingHG,
  title={Follicle-stimulating hormone--regulated granulosa cell steroidogenesis: involvement of the calcium-calmodulin system.},
  author={J. A. Carnegie and Benjamin K Tsang},
  journal={American journal of obstetrics and gynecology},
  year={1983},
  volume={145 2},
  pages={
          223-8
        }
}
  • J. Carnegie, B. Tsang
  • Published 15 January 1983
  • Biology, Medicine, Chemistry
  • American journal of obstetrics and gynecology
Sources of calcium and the involvement of calmodulin during steroidogenesis and oocyte maturation in follicles of Rana pipiens.
TLDR
Experiments using calcium antagonists suggest that Ca2+, acting through calmodulin at some specific step(s) distal to cAMP elevation and prior to pregnenolone formation, is involved in FPH-induced progesterone accumulation, apparently with the participation of both extracellular and intracellular pools of Ca2+.
Influence of A23187 and dibutyryl cyclic AMP on progestagen production by rat granulosa cells in vitro.
TLDR
It is concluded that the calcium ionophore A23187 and (Bu)2cAMP have similar as well as distinct effects on progesterone production in rat granulosa cells in vitro.
Influence of A 23187 and dibutyryl cyclic AMP on progestagen production by rat granulosa cells in vitro
TLDR
While cAMP may be involved in the more rapid control by gonadotrophin of the production of the steroid via increased synthesis of pregnenolone and/or its metabolism to 20\g=a\-OH-P, calcium may be important in the synthesis and metabolism of pregnanolone for the maintenance of steroidogenic capacity of the granulosa cells.
Microtubules and the calcium-dependent regulation of rat granulosa cell steroidogenesis.
TLDR
Using immunofluorescence and morphometric analysis, alterations in microtubule organization and overall cell shape are determined in response to ionophore-stimulated production of progesterone and 20 alpha-hydroxypregn-4-en-3-one (20 alpha-OH-progesterone) during 24 h of culture.
Fetal Calf Serum: Eliciting Phosphorylation of Ca++/Calmodulin-Dependent Protein Kinase II in Cultured Rat Granulosa Cells
TLDR
Two multifunctional protein kinases are thought to mediate intracellular signals in granulosa cells and phorbol ester inhibits FSH actions, such as cAMP formation, LH receptor expression, cholesterol side-chain cleavage enzyme synthesis, and progesterone production.
Synergistic effects between FSH and 1,1-dichloro-2,2-bis(P-chlorophenyl)ethylene (P,P'-DDE) on human granulosa cell aromatase activity.
TLDR
Concentrations of DDE similar to those present in human follicular fluid enhance basal and FSH-stimulated granulosa cell aromatizing enzyme activity.
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