Corpus ID: 8381164

Folic acid. Monograph.

@article{2005FolicAM,
  title={Folic acid. Monograph.},
  author={},
  journal={Alternative medicine review : a journal of clinical therapeutic},
  year={2005},
  volume={10 3},
  pages={
          222-9
        }
}
  • Published 2005
  • Medicine
  • Alternative medicine review : a journal of clinical therapeutic
Introduction Folic acid, also known generically as folate or folacin, is a member of the B-complex family of vitamins, and works in concert with vitamin B12. Folic acid functions primarily as a methyl-group donor involved in many important body processes, including DNA synthesis. Therapeutically, folic acid is instrumental in reducing homocysteine levels and the occurrence of neural tube defects. It may play a key role in preventing cervical dysplasia and protecting against neoplasia in… Expand
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References

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Accumulation of plasma reduced folates after folic acid administration.
TLDR
Repetitive oral administration every 6 hours resulted in consistently elevated levels of each metabolite pool with the same general saturation behavior as observed with single dose administration. Expand
Is disordered folate metabolism the basis for the genetic predisposition to neural tube defects?
TLDR
Red cell folate levels showed a linear relationship with the number of neural tube defect pregnancies, the levels being lowest in women who had had three or four affected offspring. Expand
A long-term study of the absorption of large oral doses of folic acid.
TLDR
Findings suggest that the folate stores of the body do not expand by orders of magnitude even when megadoses of folates are absorbed in the gut, as seen in hyperuricemic men. Expand
[Pharmacokinetics and relative bioavailability of iron and folic acid in healthy volunteers].
The pharmacokinetics and the relative bioavailability of iron and of folic acid was investigated in a randomized, balanced 2-way cross-over study with 14 healthy male participants. The drugs wereExpand
Plasma total homocysteine in healthy subjects: sex-specific relation with biological traits.
TLDR
Stepwise-multiple-regression analyses showed that the sex-specific influence of biological variables on tHcy concentrations was twice as important in healthy women than in healthy men and underlines the importance of considering these in the determination of threshold values. Expand
Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.
TLDR
It is concluded that heterozygosity for CBS deficiency does not appear to be involved in premature cardiovascular disease, however, a frequent homozygous mutation in the MTHFR gene is associated with a threefold increase in risk for prematurely cardiovascular disease. Expand
Relative bioavailability of deuterium-labeled monoglutamyl tetrahydrofolates and folic acid in human subjects.
TLDR
Differences exist in the bioavailability of monoglutamyl folates under these experimental conditions, and variation, whether due to differences in absorption or postabsorptive events, must be considered in quantitative studies of folate utilization with this type of protocol. Expand
Transport characteristics of folates in cerebrospinal fluid; a study utilizing doubly labeled 5-methyltetrahydrofolate and 5-formyltetrahydrofolate.
TLDR
Findings indicated that 5-methyltetrahydrofolate was taken up preferentially into the spinal fluid and that the other folate congeners were converted to this compound before uptake. Expand