Folic acid supplementation lowers blood arsenic.

  title={Folic acid supplementation lowers blood arsenic.},
  author={M. Gamble and Xinhua Liu and Vesna N Slavkovich and J. Richard Pilsner and Vesna Ilievski and Pam Factor-Litvak and Diane Levy and Shafiul Alam and Mominul Islam and Faruque Parvez and Habibul Ahsan and Joseph H. Graziano},
  journal={The American journal of clinical nutrition},
  volume={86 4},
BACKGROUND Chronic arsenic exposure currently affects >100 million persons worldwide. Methylation of ingested inorganic arsenic (InAs) to monomethylarsonic (MMAs) and dimethylarsinic (DMAs) acids relies on folate-dependent one-carbon metabolism and facilitates urinary arsenic elimination. OBJECTIVE We hypothesized that folic acid supplementation to arsenic-exposed Bangladeshi adults would increase arsenic methylation and thereby lower total blood arsenic. DESIGN In this randomized, double… CONTINUE READING


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