Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival.

@article{Marean2011FolicAS,
  title={Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival.},
  author={Amber Marean and Amanda E. Graf and Ying Zhang and Lee Niswander},
  journal={Human molecular genetics},
  year={2011},
  volume={20 18},
  pages={3678-83}
}
Neural tube defects (NTDs), a common birth defect in humans, result from the failure of the embryonic neural tube (NT) to close properly. NT closure is a complex, poorly understood morphogenetic process influenced by genes and environment. The most effective environmental influence in decreasing the risk for NTDs is folic acid (FA) fortification and supplementation, and these findings led to the recommendation of periconceptual FA intake and mandatory fortification of the US grain supply in… CONTINUE READING
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