Folic acid supplementation and cancer risk: A meta‐analysis of randomized controlled trials

  title={Folic acid supplementation and cancer risk: A meta‐analysis of randomized controlled trials},
  author={Xianhui Qin and Yi-min Cui and Lin Shen and Ningling Sun and Yan Zhang and Jianping Li and Xin Xu and Bin-yan Wang and Xiping Xu and Yong Huo and Xiaobin Wang},
  journal={International Journal of Cancer},
There are growing data and a continuing controversy over the effect of folic acid supplementation on cancer risk. We conducted a meta‐analysis based on up‐to‐date published relevant randomized trials to further examine this issue. Relative risk (RR) was used to measure the effect of folic acid supplementation on risk of cancer using a random‐effects model. Overall, folic acid supplementation had no significant effect on total cancer incidence (13 trials, n = 49,406, RR = 1.05; 95% CI: 0.99–1.11… 

Effect of vitamin B supplementation on cancer incidence, death due to cancer, and total mortality

Vitamin B supplementation is associated with a lower risk of skin melanoma, but has no effect on other cancers, and the nonsignificance of the effect of vitamin B persisted.

Effect of folic acid supplementation on cancer risk among adults with hypertension in China: A randomized clinical trial

The data suggest a protective effect in participants with MTHFR TT genotype and low folate levels, and there is no evidence that 0.8 mg daily folic acid supplementation can increase the risk of cancer incidence among adults with hypertension without history of stroke or MI in China.

Folate intake and the risk of prostate cancer: a systematic review and meta-analysis

Results are limited by the predominance of included studies originating from developed countries with mostly Caucasian populations, and further research in populations with a high prevalence of non-Caucasian backgrounds is needed.

Supplemental folic acid in pregnancy and maternal cancer risk.

Dietary B-Vitamin Intake and Risk of Breast, Endometrial, Ovarian and Colorectal Cancer among Canadians

Dietary intake of folate may reduce risk of endometrial and ovarian cancers and dietary intake of vitamin B6 may reduced risk of ovarian cancer.

Nutrition and prostate cancer: review of the evidence

The evidence on any potential association between diet and prostate cancer is weak, and the reductionist approach considering individual nutritional factors is not suitable, and conducting more observational studies or small randomised trials evaluating the impact ofindividual nutritional factors on prostate cancer will not bring further answers.

Folic acid fortification and colorectal cancer risk.

Folate and Its Impact on Cancer Risk

Findings of mixed results between folate intake, serum levels, gene polymorphisms, and cancer risk based on meta-analyses from the past five years are summarized.



Cancer risk with folic acid supplements: a systematic review and meta-analysis

Prostate cancer was the only cancer type found to be increased after folic acid supplementation after controlled studies, and a meta-analysis of 10 RCTs showed a borderline significant increase in frequency of overall cancer in the folic Acid group compared to controls.

Folic acid and risk of prostate cancer: results from a randomized clinical trial.

Data regarding the association between folate status and risk of prostate cancer are sparse and conflicting. We studied prostate cancer occurrence in the Aspirin/Folate Polyp Prevention Study, a

A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma.

Folic acid supplementation may be beneficial among those with lower folate concentrations at baseline, and there was no evidence for an increased risk of advanced or multiple adenomas.

Folic acid for the prevention of colorectal adenomas: a randomized clinical trial.

Folic acid at 1 mg/d does not reduce colorectal adenoma risk and is associated with higher risks of having 3 or more adenomas and of noncolorectAL cancers.

Cancer incidence and mortality after treatment with folic acid and vitamin B12.

Treatment with folic acid plus vitamin B(12) was associated with increased cancer outcomes and all-cause mortality in patients with ischemic heart disease in Norway, where there is no folic Acid fortification of foods.

Folic acid therapy and cardiovascular disease in ESRD or advanced chronic kidney disease: a meta-analysis.

  • X. QinY. Huo Xiaobin Wang
  • Medicine, Biology
    Clinical journal of the American Society of Nephrology : CJASN
  • 2011
Folic acid therapy can reduce CVD risk in patients with ESRD/ACKD by 15% and a greater beneficial effect was observed among those trials with no or partial folic acid fortification or a decrease in Hcy level >20% regardless of folic Acid fortification.

Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial.

Combined folic acid, vitamin B(6), anditamin B(12) treatment had no significant effect on overall risk of total invasive cancer or breast cancer among women among women during the folic Acid fortification era.

Folic acid supplementation inhibits recurrence of colorectal adenomas: a randomized chemoprevention trial.

High dose folic Acid supplementation is associated with a significant reduction in the recurrence of colonic adenomas suggesting that folic acid may be an effective chemopreventive agent for colorectal neoplasia.