Folic acid supplementation and cancer risk: A meta‐analysis of randomized controlled trials

@article{Qin2013FolicAS,
  title={Folic acid supplementation and cancer risk: A meta‐analysis of randomized controlled trials},
  author={Xianhui Qin and Yi-min Cui and Lin Shen and Ningling Sun and Yan Zhang and Jianping Li and Xin Xu and Bin-yan Wang and Xiping Xu and Yong Huo and Xiaobin Wang},
  journal={International Journal of Cancer},
  year={2013},
  volume={133}
}
There are growing data and a continuing controversy over the effect of folic acid supplementation on cancer risk. We conducted a meta‐analysis based on up‐to‐date published relevant randomized trials to further examine this issue. Relative risk (RR) was used to measure the effect of folic acid supplementation on risk of cancer using a random‐effects model. Overall, folic acid supplementation had no significant effect on total cancer incidence (13 trials, n = 49,406, RR = 1.05; 95% CI: 0.99–1.11… 

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