Folic acid supplementation and cancer risk: A meta‐analysis of randomized controlled trials

@article{Qin2013FolicAS,
  title={Folic acid supplementation and cancer risk: A meta‐analysis of randomized controlled trials},
  author={X. Qin and Yimin Cui and Lin Shen and N. Sun and Y. Zhang and Jianping Li and X. Xu and Binyan Wang and Xiping Xu and Y. Huo and Xiaobin Wang},
  journal={International Journal of Cancer},
  year={2013},
  volume={133}
}
There are growing data and a continuing controversy over the effect of folic acid supplementation on cancer risk. We conducted a meta‐analysis based on up‐to‐date published relevant randomized trials to further examine this issue. Relative risk (RR) was used to measure the effect of folic acid supplementation on risk of cancer using a random‐effects model. Overall, folic acid supplementation had no significant effect on total cancer incidence (13 trials, n = 49,406, RR = 1.05; 95% CI: 0.99–1.11… Expand
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