Folic acid prevents congenital malformations in the offspring of diabetic mice.

@article{Oyama2009FolicAP,
  title={Folic acid prevents congenital malformations in the offspring of diabetic mice.},
  author={Kaori Oyama and Yoshihisa Sugimura and Takashi Murase and Akira Uchida and Shizu Hayasaka and Yutaka Oiso and Yoshiharu Matsuura Murata},
  journal={Endocrine journal},
  year={2009},
  volume={56 1},
  pages={29-37}
}
It is well known that maternal diabetes causes various congenital malformations. Although there are many reports that folic acid (FA) administration in pregnancy reduces the risk of birth defects including neural tube defects (NTDs), a precise analysis on the preventive effect of FA against diabetic embryopathy has not been done yet. In this study, we analyzed the preventive effects of FA on congenital malformations including NTDs, cardiovascular, and skeletal malformations using a diabetic… CONTINUE READING
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