Folic acid inhibits endothelial cell proliferation through activating the cSrc/ERK 2/NF-κB/p53 pathway mediated by folic acid receptor

@article{Lin2012FolicAI,
  title={Folic acid inhibits endothelial cell proliferation through activating the cSrc/ERK 2/NF-κB/p53 pathway mediated by folic acid receptor},
  author={Shichong Lin and Wook Ryun Lee and Yi-Fan Su and Sung-Po Hsu and Hsu-Chen Lin and Pei-Yin Ho and Tien-Chi Hou and Yu-Pei Chou and Chun-Ting Kuo and Wen-Sen Lee},
  journal={Angiogenesis},
  year={2012},
  volume={15},
  pages={671-683}
}
Folate is important for normal cell division. Folate deficiency has been implicated in various diseases, including atherosclerosis, neural tube defects, and cancer. However, the effect of folate on angiogenesis was unclear. The aim of this study was to investigate the anti-angiogenic action of folic acid (FA). FA (0–10 μmol/L) concentration-dependently decreased DNA synthesis and proliferation in cultured human umbilical venous endothelial cells (HUVEC). Western blot analyses demonstrated that… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 27 REFERENCES

Similar Papers

Loading similar papers…