Corpus ID: 41899287

Folic acid-induced renal injury and repair. Correlation of structural and functional abnormalities.

@article{Klingler1980FolicAR,
  title={Folic acid-induced renal injury and repair. Correlation of structural and functional abnormalities.},
  author={E. Klingler and A. Evan and R. Anderson},
  journal={Archives of pathology \& laboratory medicine},
  year={1980},
  volume={104 2},
  pages={
          87-93
        }
}
Folic acid administered to rats in doses of 100, 200, 300, and 400 mg/kg of body weight resulted in alterations in renal tubular morphologic features and renal function, with the severity of the changes proportional to the dose. Renal cell incorporation of tritiated thymidine varied according to cell type and increased with the dose of folic acid. The results demonstrate (1) a spectrum of renal injury and subsequent repair; (2) a reduction in concentrating ability and creatinine clearance… Expand
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