Folic acid fortification prevents neural tube defects and may also reduce cancer risks

  title={Folic acid fortification prevents neural tube defects and may also reduce cancer risks},
  author={Margaretha J{\"a}gerstad},
  journal={Acta Paediatrica},
The prevalence of neural tube defect (NTD)‐affected pregnancies ranges between 0.4 and 2/1000 pregnancies in EU. NTDs result in severe malformations and sometimes miscarriages. Children born with NTD suffer for the rest of their life of disability and chronic healthcare issues, and many women therefore choose termination of pregnancy if NTD is diagnosed prenatally. Women planning for pregnancy are recommended to eat 400 μg folic acid/d, whereas average figures across Europe indicate intakes of… 

Real prevalence of neural tube defects in Japan: How many of such pregnancies have been terminated?

The real prevalence of total neural tube defects in Japan was approximately 1.5 times higher than that currently reported by the Japan Association of Obstetricians and Gynecologists.

A folic acid‐enriched diet attenuates prostate involution in response to androgen deprivation

The impact of a Folic acid (FA) enriched diet on prostate homeostasis and response to androgen deprivation is investigated using a mouse model.

Folic acid levels in some food staples in Ireland are on the decline: implications for passive folic acid intakes?

Bread, milk and spreads no longer contain as much folic acid as previously, which may contribute to a decrease in folate intake and therefore contribute to an increase in NTD rates.

[Evaluation of the safety of different doses of folic acid supplements in women in Brazil].

The use of supplements of up to 700 mcg of folic acid was shown to be safe and below this value, any dose of the supplement was safe.

Biological availability and efficacy of folates from bioengineered rice

A rodent feeding trial was devised to evaluate the efficacy of folate rice as a dietary folate source, and the influence of folates for DNA-synthesis in white blood cells and speciation on the functioning of the immune system was investigated.

Malaria in the Era of Food Fortification With Folic Acid

The available data suggest that the increase in folate concentration could be associated with an increase in malaria infection, and the introduction of food fortification with folic acid in malaria-endemic areas should be attended by precautionary programs to monitor the risk of malaria.

Occurrence and natural enhancement of folate in oats and barley

Folate, one of the B vitamins, has a well-established role in preventing neural tube defects (NTDs) in the developing foetus and megaloblastic anaemia. Folate intake is below recommended levels,

Birth Defects in Newborns: Spina Bifida Index at Rio Grande Do Norte State in Brazil -

Northeast region is the one that has the major incidence of SB in Brazil country, but RN state has a number lower than others states from its region and an update about therapeutic options to minimize the morbidity and mortality in newborn with SB congenital defects is made.

A B9-vitamin élettani és kórélettani jelentősége. Összegzés a folsav táplálékkiegészítőként történő alkalmazásának 30. évfordulójára

The present statistical data do not confirm such adverse health effects associated with folic acid fortification, however, several beneficial properties can be connected to the vitamin, that can be the reason why more and more countries are considering to join this program.



Effects and safety of periconceptional folate supplementation for preventing birth defects.

Folic acid, alone or in combination with vitamins and minerals, prevents NTDs but does not have a clear effect on other birth defects.

Trends in wheat-flour fortification with folic acid and iron--worldwide, 2004 and 2007.

  • Medicine
    MMWR. Morbidity and mortality weekly report
  • 2008
The worldwide percentage of wheat-flour fortification increased from 18% in 2004 to 27% in 2007, which indicated that the estimated number of persons with access to fortified wheat flour increased by approximately 540 million, and the annual number of newborns whose mothers had access tofortified wheat flour during pregnancy increased by about 14 million.

A Temporal Association between Folic Acid Fortification and an Increase in Colorectal Cancer Rates May Be Illuminating Important Biological Principles: A Hypothesis

It is hypothesize that the institution of folic acid fortification may have been wholly or partly responsible for the observed increase in colorectal cancer rates in the mid-1990s.

Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesis

  • S. Duthie
  • Biology, Medicine
    Journal of Inherited Metabolic Disease
  • 2010
Evidence from the majority of human studies indicates that dietary folate is genoprotective against colon cancer, and recent evidence describing how these mechanisms act, and interact, to modify colon cancer risk is presented.

Role of folate in colon cancer development and progression.

Animal studies in conjunction with clinical observations suggest that folate possesses the dual modulatory effects on carcinogenesis depending on the timing and dose of folate intervention, which is critical in providing safe and effective chemoprevention in humans.

Cancer risk with folic acid supplements: a systematic review and meta-analysis

Prostate cancer was the only cancer type found to be increased after folic acid supplementation after controlled studies, and a meta-analysis of 10 RCTs showed a borderline significant increase in frequency of overall cancer in the folic Acid group compared to controls.

A review of dietary factors and its influence on DNA methylation in colorectal carcinogenesis

Emerging data suggest the direct influence of certain micronutrients for example folic acid, selenium as well as interaction with toxins such as alcohol on DNA methylation may offer possible therapeutic potential as nutraceuticals on CRC carcinogenesis.

Folate status: effects on pathways of colorectal carcinogenesis.

The hypothesis that biological methylation and nucleotide synthesis are the means by which folate modulates cancer risk is supported by the epidemiological observation that a common polymorphism in the methylenetetrahydrofolate reductase gene differentially affects the relative risk of colon cancer depending on folate status.

Folic Acid Supplementation and Cancer Risk: Point

  • Young-In Kim
  • Biology, Medicine
    Cancer Epidemiology Biomarkers & Prevention
  • 2008
Folate, a water-soluble B vitamin that is present naturally in foods (e.g., green leafy vegetables, asparagus, broccoli, Brussels sprouts, citrus fruit, legumes, dry cereals, whole grain, yeast, lima