Folic acid deficiency enhances oral contraceptive-induced platelet hyperactivity.

@article{Durand1997FolicAD,
  title={Folic acid deficiency enhances oral contraceptive-induced platelet hyperactivity.},
  author={Philippe Durand and Michel Prost and Denis Blache},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1997},
  volume={17 10},
  pages={1939-46}
}
In previous studies conducted in female rats and in women, oral contraceptives (OC) were found to induce a platelet hyperactivity that was related to an oxidative stress. Because cases of megaloblastic anemia have been reported to occur in women taking OC, these treatments are suspected of depleting folate stores. In the study presented herein, which was conducted in rats, we sought to determine the influence of dietary folic acid deficiency (FD) on the thrombogenicity of OC. Animals were fed… CONTINUE READING

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