Folic acid as delivery vehicles: targeting folate conjugated fluorescent nanoparticles to tumors imaging.

@article{Ai2012FolicAA,
  title={Folic acid as delivery vehicles: targeting folate conjugated fluorescent nanoparticles to tumors imaging.},
  author={Jun Ai and Yuanhong Xu and Dan Li and Zuojia Liu and Erkang Wang},
  journal={Talanta},
  year={2012},
  volume={101},
  pages={32-7}
}
Herein, folic acid (FA) conjugated with AuNPs were introduced into the cancer cell imaging via the specific interaction between FA and the folate receptor on the cell surface. FA protected gold nanoparticles (AuNPs) was synthesized and labeled with fluorescein isothiocynate (FITC) to form the FITC-FA-AuNPs (FFANPs). As over-expressed folic acid receptor in some cancer cells and folic acid can specifically and selectively combine, the FFANPs can bind to the FR expressed on tumor cells such as… CONTINUE READING

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