Folic acid and vitamin B-12 supplementation does not favorably influence uracil incorporation and promoter methylation in rectal mucosa DNA of subjects with previous colorectal adenomas.

@article{Donk2007FolicAA,
  title={Folic acid and vitamin B-12 supplementation does not favorably influence uracil incorporation and promoter methylation in rectal mucosa DNA of subjects with previous colorectal adenomas.},
  author={Maureen van den Donk and Linette P Pellis and Jimmy W. Crott and Manon van Engeland and Pieter Friederich and Fokko M. Nagengast and Jeroen D van Bergeijk and Sybrand Y de Boer and Joel B. Mason and Frans J. Kok and Jaap Keijer and Ellen Kampman},
  journal={The Journal of nutrition},
  year={2007},
  volume={137 9},
  pages={2114-20}
}
Adequate folate availability is necessary to sustain normal DNA synthesis and normal patterns of DNA methylation and these features of DNA can be modified by methylenetetrahydrofolate reductase (MTHFR) C677T genotype. This study investigated the effect of MTHFR C677T genotype and daily supplementation with 5 mg folic acid and 1.25 mg vitamin B-12 on uracil misincorporation into DNA and promoter methylation. Subjects (n = 86) with a history of colorectal adenoma and MTHFR CC or TT genotype were… CONTINUE READING

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