Corpus ID: 1193232

Folic acid and cyanocobalamin levels in serum and erythrocytes during low-dose methotrexate therapy of rheumatoid arthritis and psoriatic arthritis patients.

@article{Leeb1995FolicAA,
  title={Folic acid and cyanocobalamin levels in serum and erythrocytes during low-dose methotrexate therapy of rheumatoid arthritis and psoriatic arthritis patients.},
  author={B. Leeb and G. Witzmann and E. Ogris and A. Studnicka-Benke and I. Andel and H. Schweitzer and J. Smolen},
  journal={Clinical and experimental rheumatology},
  year={1995},
  volume={13 4},
  pages={
          459-63
        }
}
  • B. Leeb, G. Witzmann, +4 authors J. Smolen
  • Published 1995
  • Medicine
  • Clinical and experimental rheumatology
  • OBJECTIVE To compare folic acid (FA) levels in patients being treated with methotrexate (MTX) with those of untreated patients in order to investigate potential folate depletion by MTX and its possible relationship to the drug's efficacy. METHODS In 33 patients on low-dose MTX therapy and in 24 controls, FA and cyanocobalamin (B12) levels were determined in serum and red blood cells (RBC). In addition, MTX levels in the RBC and serum were measured, and clinical and laboratory measures of… CONTINUE READING

    Topics from this paper.

    Folate supplementation during methotrexate therapy for rheumatoid arthritis.
    • 41