• Corpus ID: 74103916

Folic acid and cleft palate in brachycephalic dogs

@inproceedings{Guilloteau2006FolicAA,
  title={Folic acid and cleft palate in brachycephalic dogs},
  author={Aurelien Guilloteau and Eric Servet},
  year={2006}
}
Eric Servet graduated from a French engineering school, specializing in food ingredients and food technology, in 1999. He was an engineer for dairy industries working on pilot development and product formulation from 1999 to 2001. After a year spent in the USA working for Royal Canin USA on product stability and palatability, Eric Servet joined the Royal Canin Research and Development Department in France as a research engineer in 2002. 

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References

SHOWING 1-9 OF 9 REFERENCES

Observations on the prevention of cleft palate in dogs by folic acid and potential relevance to humans.

In a consistent breeding programme of Boston terrier dogs started in 1974, folic acid supplementation (5 mg/day) was introduced in 1981, and the frequency of cleft palate fell, giving a reduction of 76% after its introduction.

Cleft palate in domestic animals: epidemiologic features.

Many of the epidemiologic characteristics resemble features of cleft palate in humans and suggest animal breeds suitable for exploration as animal models for use by experimental teratologists, developmental biologists, and clinicians.

[Environment and genetics in the etiology of cleft lip and cleft palate with reference to the role of folic acid].

A specific scientific network at the European level has been set by the European Science Foundation, whose first step will be to establish consistent case ascertainment and data collection across Europe and to develop standardized protocols and methods of analysis.

Folic acid supplementation enhances repair of the adult central nervous system

The results show that the effects of folic acid supplementation on CNS growth processes are not restricted to the embryonic period, but can also be effective for enhancing growth, repair, and recovery in the injured adult CNS.

Maternal multivitamin use and orofacial clefts in offspring.

This study does not support the contention that only large dosages of folic acid are needed to prevent orofacial clefts and finds a 48% risk reduction for CLP among mothers who used multivitamins during the periconceptional period or who started multivitamin use during the first postconceptional month.

C677T variant form at the MTHFR gene and CL/P: a risk factor for mothers?

Results support the involvement of the folate pathway in the etiology of CL/P, and indicate an effect of the maternal genotype, rather than influence of the embryo's genotype.

Anomalies du développement du palais et des lèvres

  • Point Vét
  • 1997