Folic acid, ageing, depression, and dementia

@article{Reynolds2002FolicAA,
  title={Folic acid, ageing, depression, and dementia},
  author={Edward H. Reynolds},
  journal={BMJ : British Medical Journal},
  year={2002},
  volume={324},
  pages={1512 - 1515}
}
  • E. Reynolds
  • Published 2002
  • Medicine
  • BMJ : British Medical Journal
It is becoming clear that folic acid affects mood and cognitive function, especially in older people. Edward Reynolds draws together the evidence Folic acid is important for functioning of the nervous system at all ages.1–4 In the fetus the relation between maternal folate status and the risk of neural tube defects is well established: clinical trials have shown that periconceptual preventive treatment with 400 μg or higher of folic acid significantly reduces the risks of such defects.4 In… Expand
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: It has long been recognized that folate deficiency is associated with impaired cognitive function, particularly in older adults. Moreover, folate deficiency contributes to the symptoms of clinicalExpand
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Vitamin B12, folic acid, and the nervous system
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The evidence regarding whether substitution of folate and vitamin B 12 is beneficial, for example, in cerebrovascular disease, dementia and depression is reviewed, with particular emphasis on the evidence for prophylactic and therapeutic strategies. Expand
Association Between Folate, Vitamin B12 and Cognitive Performance in Demented Elderly.
Dementia is prevalent among elderly people. As the world population ages, it is projected that the number of people affected by dementia may triple in the next 50 years. Over the last two decades,Expand
The effects and potential mechanisms of folic acid on cognitive function: a comprehensive review
TLDR
According to data obtained from the review, it seems that folic acid supplementation may improve cognitive function by decreasing homocysteine (Hcy), vascular care, attenuating inflammatory status, modification of cerebral folic Acid deficiency, and antioxidant responses. Expand
Homocysteine, folate and vitamin B12 in neuropsychiatric diseases: review and treatment recommendations
TLDR
Evidence regarding whether substitution of folate and vitamin B12 is beneficial, for example, in cerebrovascular disease, dementia and depression is reviewed, with particular emphasis on the evidence for prophylactic and therapeutic strategies. Expand
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TLDR
Despite the plausible biochemical mechanism, further studies, based on clinical, neuropsychological, laboratory and (lastly) pathological features will be necessary to better understand this fascinating biochemical riddle. Expand
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