Folic Acid and Coenzyme Q10 Ameliorate Cognitive Dysfunction in the Rats with Intracerebroventricular Injection of Streptozotocin

@inproceedings{Dolatabadi2012FolicAA,
  title={Folic Acid and Coenzyme Q10 Ameliorate Cognitive Dysfunction in the Rats with Intracerebroventricular Injection of Streptozotocin},
  author={Hamid Reza Dehghani Dolatabadi and Parham Reisi and Hojjatallah Alaei and Hamid Azizi Malekabadi and Ali Asghar Pilehvarian},
  booktitle={Iranian journal of basic medical sciences},
  year={2012}
}
OBJECTIVES The present study aimed to investigate the effects of a fat soluble antioxidant, coenzyme Q10 (CoQ10) and folic acid on learning and memory in the rats with intracerebroventricular injection of streptozotocin (ICV-STZ), an animal model of sporadic type of Alzheimer's disease. MATERIALS AND METHODS The lesion groups were injected bilaterally with ICV-STZ (1.5 mg/kg b.wt., in normal saline). In the treated groups, rats received folic acid (4 mg/kg; i.p.) or CoQ10 (10 mg/kg; i.p… CONTINUE READING