Folic Acid Supplementation during Pregnancy Induces Sex-Specific Changes in Methylation and Expression of Placental 11β-Hydroxysteroid Dehydrogenase 2 in Rats

@article{Peailillo2015FolicAS,
  title={Folic Acid Supplementation during Pregnancy Induces Sex-Specific Changes in Methylation and Expression of Placental 11$\beta$-Hydroxysteroid Dehydrogenase 2 in Rats},
  author={Reyna Pe{\~n}ailillo and Ang{\'e}lica Guajardo and Miguel Llanos and Sandra Hirsch and Ana Mar{\'i}a Ronco},
  journal={PLoS ONE},
  year={2015},
  volume={10}
}
In the placenta, 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) limits fetal glucocorticoid exposure and its inhibition has been associated to low birth weight. Its expression, encoded by the HSD11B2 gene is regulated by DNA methylation. We hypothesized that maternal diets supplemented with folic acid (FA) during pregnancy modify the expression of placental HSD11B2 through gene methylation. Wistar rats were fed with high (8 mg/kg) or normal low (1mg/kg, control) levels of FA during… 
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Although differentially expressed genes were associated with response to nutrients and developmental processes, no correspondence was found with the differentially methylated regions, suggesting that cellular responses to SAM treatment during early embryo development may not require DNA methylation-driven changes.
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[Folate and Pregnancy, current concepts: It is required folic acid supplementation?]
TLDR
It is thought that, after 16 years of the initiation of the fortification of wheat flour with FA, it is necessary to evaluate the possible side effects of a high intake of FA in the pregnant population and their offspring.
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