Folic Acid Modulates Matrix Metalloproteinase-2 Expression, Alleviates Neuropathic Pain, and Improves Functional Recovery in Spinal Cord-Injured Rats.

@article{Miranpuri2017FolicAM,
  title={Folic Acid Modulates Matrix Metalloproteinase-2 Expression, Alleviates Neuropathic Pain, and Improves Functional Recovery in Spinal Cord-Injured Rats.},
  author={Gurwattan S. Miranpuri and Sivan Vadakkadath Meethal and Emmanuel Sampene and Abhishek Chopra and Seah Buttar and Carrie Nacht and Neydis Moreno and Kush R Patel and Lisa Liu and Anupama Singh and Chandra Kant Singh and Nithya Hariharan and Bermans J. Iskandar and Daniel K. Resnick},
  journal={Annals of neurosciences},
  year={2017},
  volume={24 2},
  pages={74-81}
}
BACKGROUND The molecular underpinnings of spinal cord injury (SCI) associated with neuropathic pain (NP) are unknown. Recent studies have demonstrated that matrix metalloproteinases (MMPs) such as MMP2 play a critical role in inducing NP following SCI. Promoter methylation of MMPs is known to suppress their transcription and reduce NP. In this context, it has been shown in rodents that folic acid (FA), an FDA approved dietary supplement and key methyl donor in the central nervous system (CNS… CONTINUE READING

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