Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model

@article{Sahakyan2018FolicAE,
  title={Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model},
  author={Vardine Sahakyan and Robin Duelen and Wai Long Tam and Scott S. J. Roberts and Hanne Grosemans and Pieter Berckmans and Gabriele Ceccarelli and Gloria Pelizzo and Vania Broccoli and Jan A Deprest and Frank P. Luyten and Catherine M. Verfaillie and Maurilio Sampaolesi},
  journal={Scientific Reports},
  year={2018},
  volume={8}
}
  • Vardine Sahakyan, Robin Duelen, +10 authors Maurilio Sampaolesi
  • Published in Scientific Reports 2018
  • Biology, Medicine
  • Neural tube defects (NTDs) are severe congenital abnormalities, caused by failed closure of neural tube during early embryonic development. Periconceptional folic acid (FA) supplementation greatly reduces the risk of NTDs. However, the molecular mechanisms behind NTDs and the preventive role of FA remain unclear. Here, we use human induced pluripotent stem cells (iPSCs) derived from fetuses with spina bifida aperta (SBA) to study the pathophysiology of NTDs and explore the effects of FA… CONTINUE READING

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