Folic Acid

  title={Folic Acid},
  author={James G. Donnelly},
  journal={Critical Reviews in Clinical Laboratory Sciences},
  pages={183 - 223}
  • J. G. Donnelly
  • Published 2001
  • Critical Reviews in Clinical Laboratory Sciences
Referee: S Hill, McMaster University, Hamilton, Canada Folic acid is an essential nutrient from the B complex group of vitamins. Folate, as a cofactor, is involved in numerous intracellular reactions, and this is reflected in the various derivatives that have been isolated from biological sources. Folic acid is involved in single carbon transfer reactions and serves as a source of single carbon units in different oxidative states. The processes involved in the absorption, transport, and… Expand
6 Citations
Folic Acid Supplementation in Patients with Elevated Homocysteine Levels
Folic acid supplementation should be recommended to any patient who has an elevated Hcy level, and this level should be measured and treated at an early age, since folic acid is easily obtained and may likely reduce vascular disease and other deleterious pathologic processes in high-risk populations. Expand
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The tools are now at hand to complete understanding of the steps in folate absorption and metabolism, which should facilitate the management of folate deficiency whenever it complicates gastrointestinal disease or drug therapy. Expand
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  • B. Shane
  • Biology, Medicine
  • Vitamins and hormones
  • 1989
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  • I. Chanarin
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  • Critical reviews in toxicology
  • 1982
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Comparison of Folic Acid Coenzyme Distribution Patterns in Patients with Methylenetetrahydrofolate Reductase and Methionine Synthetase Deficiencies
The results support the “methyl-THF trap” hypothesis and offer information with respect to the possible therapy of these two disorders. Expand
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  • S. Mudd
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  • 1979
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