Folic Acid: Discovery and the Exciting First Decade
@article{Welch1983FolicAD, title={Folic Acid: Discovery and the Exciting First Decade}, author={Arnold deM. Welch}, journal={Perspectives in Biology and Medicine}, year={1983}, volume={27}, pages={64 - 75} }
Several detailed reviews of the subject covered in this article have been presented; of these, four of the earliest were those of Snell and Wright [1], Welch and Heinle [2], Jukes and Stokstad [3], and Welch and Nichol [4]· Studies in 1941 and 1942 (Black, McKibbin, and Elvehjem [5]; Black, Overman, Elvehjem, and Link [6]; Welch [7]; Welch, Mattis, and Latven [8]; Welch and Wright [9]; Daft, Ashburn, and Sebrell [10]) of the effects on growing rats of highly purified diets containing…
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References
SHOWING 1-10 OF 75 REFERENCES
Chemical Antagonism of Pteroylglutamic Acid in a Pig; Hematopoietic Effect of Extrinsic and Intrinsic Factors.∗
- BiologyProceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
- 1947
Summary Interference with the metabolism of pteroylglutamic acid in the pig, through the use of a crude chemical antagonist, interrupts growth and significantly inhibits the formation of erythrocytes…
Some observations on the effect of folic acid antagonists on acute leukemia and other forms of incurable cancer.
- MedicineBlood
- 1949
No evidence has been presented which would justify the use of the word "cure" of acute leukemia, and two of the most pressing problems demanding solution are concerned with the nature, the prevention, and the treatment of toxic changes, including hemorrhage, produced by these folic acid antagonists.
THE ROLE OF CONJUGATED AND FREE FORMS OF FOLIC ACID IN THE CONTROL OF PERNICIOUS ANEMIA: II. BIOCHEMICAL ASPECTS
- Medicine, Biology
- 1946
In patients with pernicious anemia, the conjugated folic acid of yeast is not broken down appreciably to release L. casei factor, and its failure to appear as such in the urine suggests that it is either destroyed or, more probably, stored in the tissues.
The Chemistry and Biological Action of Pteroylglutamic Acid and Related Compounds
- Biology, Chemistry
- 1948
Biological studies with 4-amino-10-methylpteroylglutamic acid.
- Biology, ChemistryThe Journal of biological chemistry
- 1949
Folic acid antagonists in the treatment of acute and subacute leukemia.
- MedicineBlood
- 1950
Cases of acute and subacute leukemia were treated with one or more of various folic acid antagonists, usually aminopterin, and observed remissions, which indicate that acute leukemia is not necessarily completely irreversible.
THE PRODUCTION OF FOLIC ACID BY RAT LIVER IN VITRO
- Biology, ChemistryScience
- 1943
The data presented favor the last hypothesis and suggest that xanthopterin, or a substance derived from it, may constitute a portion of the folic acid molecule.