Folic Acid: Discovery and the Exciting First Decade

@article{Welch1983FolicAD,
  title={Folic Acid: Discovery and the Exciting First Decade},
  author={Arnold deM. Welch},
  journal={Perspectives in Biology and Medicine},
  year={1983},
  volume={27},
  pages={64 - 75}
}
  • A. D. Welch
  • Published 7 January 2015
  • Biology
  • Perspectives in Biology and Medicine
Several detailed reviews of the subject covered in this article have been presented; of these, four of the earliest were those of Snell and Wright [1], Welch and Heinle [2], Jukes and Stokstad [3], and Welch and Nichol [4]· Studies in 1941 and 1942 (Black, McKibbin, and Elvehjem [5]; Black, Overman, Elvehjem, and Link [6]; Welch [7]; Welch, Mattis, and Latven [8]; Welch and Wright [9]; Daft, Ashburn, and Sebrell [10]) of the effects on growing rats of highly purified diets containing… 

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References

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Summary Interference with the metabolism of pteroylglutamic acid in the pig, through the use of a crude chemical antagonist, interrupts growth and significantly inhibits the formation of erythrocytes
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TLDR
No evidence has been presented which would justify the use of the word "cure" of acute leukemia, and two of the most pressing problems demanding solution are concerned with the nature, the prevention, and the treatment of toxic changes, including hemorrhage, produced by these folic acid antagonists.
THE ROLE OF CONJUGATED AND FREE FORMS OF FOLIC ACID IN THE CONTROL OF PERNICIOUS ANEMIA: II. BIOCHEMICAL ASPECTS
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In patients with pernicious anemia, the conjugated folic acid of yeast is not broken down appreciably to release L. casei factor, and its failure to appear as such in the urine suggests that it is either destroyed or, more probably, stored in the tissues.
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TLDR
Cases of acute and subacute leukemia were treated with one or more of various folic acid antagonists, usually aminopterin, and observed remissions, which indicate that acute leukemia is not necessarily completely irreversible.
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TLDR
The data presented favor the last hypothesis and suggest that xanthopterin, or a substance derived from it, may constitute a portion of the folic acid molecule.
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